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Their studies fail to control for things like previous weight cycling, food insecurity, genetics, allostatic load, trauma, stigma, discrimination, and other social determinants of health.9 According to the world health organization, social determinants of health account for between 30-55% of health outcomes.10 The FDA uses this body of research that the industry has created to inform its approval decisions and since the overall theme is fat=bad, thin=good, even if the reality is far more complicated and nuanced than this, approval was granted, even with no long term data on safety and efficacy at this higher dose.8,9 A glaring problem here is that we know anti-fat bias in medicine and society leads to worse health outcomes.11 A lot of the health conditions that people in larger bodies deal with can be attributed to the stress that comes with being treated poorly almost all of the time yet they are told its solely due to their weight and that its only the individuals fault

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72 PCSK9 Inhibitors The newest medications on the scene are agents that directly inhibit the enzyme PCSK9, effectively removing an inhibitor in the LDL receptor pathway

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